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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4975
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pubmed:dateCreated |
1990-10-26
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pubmed:databankReference |
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pubmed:abstractText |
The primary structure of lipopolysaccharide binding protein (LBP), a trace plasma protein that binds to the lipid A moiety of bacterial lipopolysaccharides (LPSs), was deduced by sequencing cloned complementary DNA. LBP shares sequence identity with another LPS binding protein found in granulocytes, bactericidal/permeability-increasing protein, and with cholesterol ester transport protein of the plasma. LBP may control the response to LPS under physiologic conditions by forming high-affinity complexes with LPS that bind to monocytes and macrophages, which then secrete tumor necrosis factor. The identification of this pathway for LPS-induced monocyte stimulation may aid in the development of treatments for diseases in which Gram-negative sepsis or endotoxemia are involved.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
249
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1429-31
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2402637-Acute-Phase Proteins,
pubmed-meshheading:2402637-Amino Acid Sequence,
pubmed-meshheading:2402637-Animals,
pubmed-meshheading:2402637-Base Sequence,
pubmed-meshheading:2402637-Blood Proteins,
pubmed-meshheading:2402637-Carrier Proteins,
pubmed-meshheading:2402637-Gene Library,
pubmed-meshheading:2402637-Humans,
pubmed-meshheading:2402637-Kinetics,
pubmed-meshheading:2402637-Lipid A,
pubmed-meshheading:2402637-Lipopolysaccharides,
pubmed-meshheading:2402637-Male,
pubmed-meshheading:2402637-Membrane Glycoproteins,
pubmed-meshheading:2402637-Molecular Sequence Data,
pubmed-meshheading:2402637-Oligonucleotide Probes,
pubmed-meshheading:2402637-Rabbits,
pubmed-meshheading:2402637-Sequence Homology, Nucleic Acid,
pubmed-meshheading:2402637-Sheep,
pubmed-meshheading:2402637-Staphylococcus aureus,
pubmed-meshheading:2402637-Tumor Necrosis Factor-alpha
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pubmed:year |
1990
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pubmed:articleTitle |
Structure and function of lipopolysaccharide binding protein.
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pubmed:affiliation |
Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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