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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1990-10-26
|
| pubmed:abstractText |
The presence of epidermal growth factor receptor (EGF-R) and blood group A antigen was studied immunohistochemically in a series of 110 malignant gliomas using monoclonal antibodies. Fifty-seven percent of the tumours strongly expressed EGF-R on the malignant cells. Although blood group A antigen is present on EGF-R of A431 cells (a cell line derived from a human epidermoid carcinoma), in gliomas it was found only on vascular endothelial cells of tumours from blood group A patients. The results suggest that the EGF-R present in gliomas differs from that in A431 cells in the type or amount of the carbohydrate chains. This is in contrast to previous reports which have suggested that A antigen is present on EGF-R in gliomas. This has relevance in the choice of monoclonal antibodies used to study the EGF-R, as those directed against the A antigen component of the A431 cell EGF-R will not recognize EGF-R elsewhere and may cause normal blood group A antigen to be mistaken for EGF-R.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0305-1846
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
185-92
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading | |
| pubmed:year |
1990
|
| pubmed:articleTitle |
Investigation of the expression of epidermal growth factor receptor and blood group A antigen in 110 human gliomas.
|
| pubmed:affiliation |
Department of Neuropathology, Radcliffe Infirmary, Oxford.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|