Linked Life Data

2401938

Source:http://linkedlifedata.com/resource/pubmed/id/2401938

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1990-10-19
pubmed:abstractText
Lipopolysaccharide (LPS) is in large part responsible for the lung injury that occurs in the sepsis syndrome. Recent work has shown the ability of LPS alone to induce injury in endothelial monolayers, though the LPS effect is enhanced in the presence of serum. We previously demonstrated that low-dose LPS (50 ng/mL) can lead to lung injury in an isolated perfused rabbit lung model. To examine the effect of serum on LPS-induced injury rabbit lungs were perfused with increasing doses of rabbit serum in the presence and absence of LPS. There was no increase in total weight gained by the lung,Qf, with either 5% serum, 10% serum, or 10% serum with LPS. However vascular permeability as measured by hydraulic conductance was increased with increasing doses of serum. This effect was not enhanced by the addition of LPS. These results provide evidence that serum alone may cause lung injury, perhaps through the activation of complement or other mediators.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-3468
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
846-8; discussion 849
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Effects of serum and endotoxin in experimental lung injury.
pubmed:affiliation
Department of Pediatrics, Baylor College of Medicine, Houston, TX.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't