Linked Life Data

2401682

Source:http://linkedlifedata.com/resource/pubmed/id/2401682

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-10-24
pubmed:abstractText
Prostaglandin E2 (PGE2) is a very important immunosuppressive substance that is synthesized and released by all macrophages including Kupffer cells (KCs). In this study the changes of PGE2 released by KCs were evaluated in a burned guinea pig model. Prostaglandin E2 was released by KCs from burned guinea pigs at a consistently and significantly high level when stimulated with endotoxin. On postburn day 8, KCs that were cocultured with hepatocytes released significantly less PGE2. There was also a significant decrease in antibody-dependent cell-mediated cytotoxicity on postburn day 1. Kupffer cells can mediate immune suppression in burn injury by a prolonged increased production of PGE2 that has immunosuppressive effects on other cells and by a decreased cytotoxic effect soon after burn injury.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0273-8481
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
287-94
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
The increased release of prostaglandin E2 by Kupffer cells from burned guinea pigs.
pubmed:affiliation
Shriners Burns Institute, Cincinnati, OH 45219.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't