Linked Life Data

2399936

Source:http://linkedlifedata.com/resource/pubmed/id/2399936

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-10-12
pubmed:abstractText
The morphologic evolution of hepatitis B virus (HBV) liver disease in 45 hepatic allograft recipients who were HBV surface-antigen positive (HBs-Ag+) at the time of liver replacement and who survived for more than 60 days was studied by routine histologic and immunocytochemical analysis of serial pathology specimens. The findings in these patients were compared to a control group of 30 individuals who were immune to the HBV (anti-HBs antibody positive), but required hepatic replacement for other reasons. Eight of the forty-five (18%) HBsAg-positive patients have no serologic evidence of HBV reinfection after transplantation. All 37 remaining patients are reinfected; 21 (47%) developed chronic active hepatitis and/or cirrhosis, 3 (7%) developed submassive necrosis, and 6 (14%) developed chronic lobular hepatitis. One patient lost her graft to chronic rejection, despite reinfection with the B virus. Four other patients (9%) developed a chronic carrier state. No long-term follow-up biopsies were available in the remaining two patients. The histologic features associated with dysfunction related to recurrent HBV infection evolved from an acute to chronic phase and were similar to hepatitis B seen in nonallografted livers. Furthermore HBV-related lesions could be separated from rejection using routine histology alone. The only exception to this conclusion was the occurrence of a peculiar HBV-related lesion in two recipients, described herein. Immunohistochemical analysis demonstrated the presence of viral antigens in almost all cases. Hepatic inflammation also was commonly present during HBV disease and consisted mostly of accessory cells and T lymphocytes. Analysis of the effect of major histocompatibility complex matching revealed no clear association between the number of class I or II matches or mismatches and the development, or pattern, of active hepatitis in the allograft. Peculiar pathologic alterations in several of the biopsies and failed allografts after HBV reinfection suggests that, under special circumstances, the B virus may be cytopathic.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2399936-202371, http://linkedlifedata.com/resource/pubmed/commentcorrection/2399936-2671579, http://linkedlifedata.com/resource/pubmed/commentcorrection/2399936-2887774, http://linkedlifedata.com/resource/pubmed/commentcorrection/2399936-3053890, http://linkedlifedata.com/resource/pubmed/commentcorrection/2399936-3286466, http://linkedlifedata.com/resource/pubmed/commentcorrection/2399936-3313997, http://linkedlifedata.com/resource/pubmed/commentcorrection/2399936-3313999, http://linkedlifedata.com/resource/pubmed/commentcorrection/2399936-3515681, http://linkedlifedata.com/resource/pubmed/commentcorrection/2399936-3535528, http://linkedlifedata.com/resource/pubmed/commentcorrection/2399936-3547807, http://linkedlifedata.com/resource/pubmed/commentcorrection/2399936-365134, http://linkedlifedata.com/resource/pubmed/commentcorrection/2399936-3892154
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0002-9440
pubmed:author
pubmed:issnType
Print
pubmed:volume
137
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
667-76
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Evolution of hepatitis B virus liver disease after hepatic replacement. Practical and theoretical considerations.
pubmed:affiliation
Department of Pathology, Presbyterian University Hospital, University of Pittsburgh, PA 15213.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't