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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1990-10-16
|
| pubmed:abstractText |
We report here the identification of a 4 bp deletion in the A gamma T globin gene promoter by means of Fnu4HI digestion of DNA amplified by polymerase chain reaction (PCR). This deletion has been previously associated with haplotype II beta-thalassemia in Sardinia. This simple, non-radioactive procedure should facilitate the screening of various populations of normal and beta-thalassemic subjects for this specific genetic alteration.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0361-8609
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
131-3
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:2399905-Chromosome Deletion,
pubmed-meshheading:2399905-DNA,
pubmed-meshheading:2399905-Electrophoresis, Agar Gel,
pubmed-meshheading:2399905-Globins,
pubmed-meshheading:2399905-Humans,
pubmed-meshheading:2399905-Polymerase Chain Reaction,
pubmed-meshheading:2399905-Promoter Regions, Genetic,
pubmed-meshheading:2399905-Thalassemia
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Polymerase chain reaction amplification applied to the direct detection of a 4 bp deletion in the promoter region of the A gamma gene.
|
| pubmed:affiliation |
Institute of General Physiology and Biological Chemistry, University of Sassari, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|