Linked Life Data

2399263

Source:http://linkedlifedata.com/resource/pubmed/id/2399263

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-10-18
pubmed:abstractText
In order to explore why ovarian hormone deficiency causes excessive osteoclastic bone resorption that results in osteoporosis in a large number of postmenopausal women, bone marrow cells from ovariectomized and sham-operated female mice were cultured for 8 days. The cells gave rise in culture to tartrate-resistant acid phosphatase-positive multinucleate cells. The formation of these osteoclast-like cells was enhanced by parathyroid hormone and 1,25(OH)2vitamin D3, with the latter being more effective. Cultures of cells from ovariectomized animals formed significantly more tartrate-resistant acid phosphatase-positive multinucleate cells than those from sham-operated controls. These findings support the hypothesis that ovarian hormone deficiency promotes the expansion of a pool of marrow-derived progenitor cells that differentiate into bone-resorbing osteoclasts under the influence of osteotropic hormones.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0037-9727
pubmed:author
pubmed:issnType
Print
pubmed:volume
195
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
70-4
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Proliferation of tartrate-resistant acid phosphatase positive multinucleate cells in ovariectomized animals.
pubmed:affiliation
Department of Physiology, University of Texas Health Science Center, San Antonio 78284.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.