Linked Life Data

2399116

Source:http://linkedlifedata.com/resource/pubmed/id/2399116

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-10-18
pubmed:abstractText
The relations between parameters of cellular energy and the release of succinate, alanine and creatine from isolated, isovolumic guinea pig hearts were studied during underperfusion (0.2 ml/min) with glucose or acetate. The heart work index (the product of the left ventricular pressure and the heart rate), tissue ATP and phosphocreatine contents did not depend upon the nature of the substrate when coronary flow was 19 ml/min. However, 50 min underperfusion with acetate resulted in a twofold increase in diastolic pressure, while glucose prevented the development of contracture. A more rapid ATP depletion accompanied by an increased succinate and creatine release was observed during underperfusion with acetate as compared with glucose. Succinate and alanine accumulation in myocardial effluent was related to a decrease in tissue ATP, while creatine release showed a close, inverse correlation with the tissue phosphocreatine/creatine ratio. Hyperbolic and linear relations were found between these indices for glucose- and acetate-perfused hearts, respectively. The results suggest that the determination of succinate, creatine and alanine in myocardial effluent may be used for assessment of the energy status of the ischemic heart.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0031-6768
pubmed:author
pubmed:issnType
Print
pubmed:volume
416
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
434-41
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Relations between the energy state of the myocardium and release of some products of anaerobic metabolism during underperfusion.
pubmed:affiliation
USSR Cardiology Research Center, Moscow.
pubmed:publicationType
Journal Article