Linked Life Data

2398440

Source:http://linkedlifedata.com/resource/pubmed/id/2398440

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-10-12
pubmed:abstractText
Single flush perfusion of the lung represents one concept of pulmonary preservation that has provided satisfactory results in both experimental and clinical situations. The technique has allowed successful distant organ procurement, with consequent enlargement of the available donor pool. Both cold modified blood (CMB) and modified Euro-Collins solution (ECS) are currently used as perfusates, although the volumes of each used clinically are different. CMB is administered at 20 ml/kg and ECS at 60 ml/kg. Both techniques combine the use of a prostaglandin to enhance preservation. In this study these two perfusion techniques were compared in a canine model of unilateral left lung allotransplantation after 6 hours of storage, with subsequent ligation of the recipient's contralateral pulmonary artery and bronchus. Equal volumes of both solutions were used (20 ml/kg) to determine whether the blood vehicle was necessary to provide good preservation at this volume. Assessment of pulmonary preservation was determined by animal survival, blood gas analyses, hemodynamic values, and measurement of lung water content. All animals survived the 24-hour experimental period in stable condition. Postoperative oxygenation was well maintained at control values throughout this period with no significant difference between groups. The pulmonary vascular resistance index was significantly higher in the CMB group at 1 hour (p less than 0.05). Lung compliance, assessed by peak-inspiratory pressure, was impaired to a greater extent in the CMB group than in the ECS animals (p less than 0.01 at 12 and 24 hours).(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0887-2570
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
429-34
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:articleTitle
Comparison of cold flush perfusion with modified blood versus modified Euro-Collins solution for lung preservation.
pubmed:affiliation
Department of Cardiothoracic Surgery, University of Newcastle upon Tyne, Newcastle, England.
pubmed:publicationType
Journal Article, Comparative Study