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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
1990-10-11
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pubmed:abstractText |
The crystal structure of the dodecanucleotide d(CGCAAGCTGGCG) has been determined to a resolution of 2.5 A and refined to an R factor of 19.3% for 1710 reflections. The sequence crystallizes as a B-type double helix, with two G(anti).A(syn) base pairs. These are stabilized by three-center hydrogen bonds to pyrimidines that induce perturbations in base-pair geometry. The central AGCT region of the helix has a wide (greater than 6 A) minor groove.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2395870-2600970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2395870-2657730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2395870-2714249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2395870-2754734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2395870-2842064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2395870-3044611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2395870-3271438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2395870-3304141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2395870-3310237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2395870-3458205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2395870-3479798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2395870-3670410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2395870-3897553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2395870-6273591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2395870-6308634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2395870-6386179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2395870-6466638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2395870-6525406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2395870-6576336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2395870-6878044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2395870-7043400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2395870-958483
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6693-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2395870-Adenine,
pubmed-meshheading:2395870-Base Composition,
pubmed-meshheading:2395870-Base Sequence,
pubmed-meshheading:2395870-Crystallization,
pubmed-meshheading:2395870-Guanine,
pubmed-meshheading:2395870-Hydrogen Bonding,
pubmed-meshheading:2395870-Models, Molecular,
pubmed-meshheading:2395870-Molecular Sequence Data,
pubmed-meshheading:2395870-Nucleic Acid Conformation,
pubmed-meshheading:2395870-Oligodeoxyribonucleotides
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pubmed:year |
1990
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pubmed:articleTitle |
Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG).
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pubmed:affiliation |
Cancer Research Campaign Biomolecular Structure Unit, Institute of Cancer Research, Sutton, Surrey, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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