Linked Life Data

2394298

Source:http://linkedlifedata.com/resource/pubmed/id/2394298

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-10-11
pubmed:abstractText
Granulocyte-macrophage colony-stimulating factor (GM-CSF), a product of activated T lymphocytes, macrophages, endothelial cells, fibroblasts, and keratinocytes, is thought to play an important role in inflammatory reactions by 'priming' or enhancing the functions of neutrophils and macrophages. The aim of this study was to determine whether GM-CSF is detectable in psoriatic lesions. No GM-CSF was detected by ELISA in the suction blister fluids raised on normal, psoriatic uninvolved or involved skin. In contrast, although we could not detect GM-CSF in most of the extracts from noninflammatory stratum corneum, it was readily detected in most of the scale extracts from psoriasis and sterile pustular dermatoses, and its level was significantly higher than that from the controls. These results suggest that in psoriasis GM-CSF may amplify and modulate inflammatory reactions and activated T cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0011-9075
pubmed:author
pubmed:issnType
Print
pubmed:volume
181
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
16-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Granulocyte-macrophage colony-stimulating factor in psoriasis.
pubmed:affiliation
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't