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pubmed-article:2392119pubmed:abstractTextThe genotoxic potential of endosulfan was assessed in mouse germ cells by 2 in vivo tests: the dominant lethal and the sperm shape abnormality test. At higher doses, endosulfan induced dominant lethal mutations in one mating interval (36-42 days) post treatment. A statistically significant dose-dependent increase in sperm abnormalities was observed with endosulfan treatment. At high doses the sperm count decreased up to 39%. No change in sperm motility was observed at any dose level. On the basis of the present in vivo results, it appears that endosulfan has a damaging effect on spermatogonial cells as well as on sperm morphology.lld:pubmed
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pubmed-article:2392119pubmed:authorpubmed-author:RayP KPKlld:pubmed
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pubmed-article:2392119pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:2392119pubmed:year1990lld:pubmed
pubmed-article:2392119pubmed:articleTitleStudies on the genotoxicity of endosulfan, an organochlorine insecticide, in mammalian germ cells.lld:pubmed
pubmed-article:2392119pubmed:affiliationEnvironmental Microbiology Section, Industrial Toxicology Research Center, Mahatma Gandhi Marg, Lucknow, India.lld:pubmed
pubmed-article:2392119pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2392119pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed