Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1990-9-27
|
pubmed:abstractText |
N-nitrosodibenzylamine (NDBzA) and N-nitroso-alpha-acetoxybenzyl-benzylamine (alpha-acetoxy-NDBzA) were tested for induction of DNA single-strand breaks (SSBs) in V 79 Chinese hamster cells (V 79 cells) and isolated rat hepatocytes. The alkaline elution assay was used for the detection of DNA strand breaks. Treatment of V 79 cells with alpha-acetoxy-NDBzA effectively increased the rate of DNA SSBs, while with NDBzA, no DNA-damaging activity was detectable. Both substances produced significant DNA damage in rat hepatocytes. Interestingly, NDBzA was able to induce SSBs at significantly lower concentrations than alpha-acetoxy-NDBzA. The possible reasons for these findings are discussed. In contrast to these in vitro results, NDBzA exhibited very weak in vivo activity.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0378-4274
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
52
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
269-77
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:2389257-Administration, Oral,
pubmed-meshheading:2389257-Animals,
pubmed-meshheading:2389257-Cell Line,
pubmed-meshheading:2389257-Cricetinae,
pubmed-meshheading:2389257-Cricetulus,
pubmed-meshheading:2389257-DNA, Single-Stranded,
pubmed-meshheading:2389257-DNA Damage,
pubmed-meshheading:2389257-Female,
pubmed-meshheading:2389257-Injections, Intraperitoneal,
pubmed-meshheading:2389257-Liver,
pubmed-meshheading:2389257-Nitrosamines,
pubmed-meshheading:2389257-Rats,
pubmed-meshheading:2389257-Rats, Inbred Strains
|
pubmed:year |
1990
|
pubmed:articleTitle |
DNA damage induced by N-nitrosodibenzylamine and N-nitroso-alpha-acetoxybenzyl-benzylamine in mammalian cell systems and in vivo.
|
pubmed:affiliation |
Max von Pettenkofer Institute, Federal Health Office, Berlin, F.R.G.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|