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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1990-9-27
|
| pubmed:abstractText |
In this study intact and suprachiasmatic nuclei (SCN)-lesioned female rats were treated with chronic methamphetamine (MA) via the drinking water. Body temperature, feeding, drinking and wheel-running activity were continuously and automatically recorded. The rats were subjected to light-dark (LD) cycles with period T = 23 hr for 4 months and subsequently T = 25 hr for 3 months. Daily 3-hr forced activity (FA 3:21) was imposed during a few weeks under both LD regimes. MA induced infradian rhythms (period tau s = 28-54 hr) that were found to run parallel in all functions. In intact rats these infradian rhythms showed relative coordination by the LD regime and tau s shortened when T lengthened. In SCN-lesioned rats, however, the infradian rhythms were independent of the LD regime. Under the FA cycles tau s lengthening as well as synchronization was observed. We hypothesized that the MA-induced rhythms reflect a long-period sleep-wake cycle of the hourglass type. We investigated this hypothesis with a modified version of the hourglass-clock model of sleep regulation. Computer simulations showed that this model might offer an explanation for the experimental observations.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0031-9384
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
47
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
917-29
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2388949-Animals,
pubmed-meshheading:2388949-Circadian Rhythm,
pubmed-meshheading:2388949-Computer Simulation,
pubmed-meshheading:2388949-Female,
pubmed-meshheading:2388949-Light,
pubmed-meshheading:2388949-Methamphetamine,
pubmed-meshheading:2388949-Motor Activity,
pubmed-meshheading:2388949-Rats,
pubmed-meshheading:2388949-Rats, Inbred Strains,
pubmed-meshheading:2388949-Sleep Stages,
pubmed-meshheading:2388949-Suprachiasmatic Nucleus
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Effects of T cycles of light/darkness and periodic forced activity on methamphetamine-induced rhythms in intact and SCN-lesioned rats: explanation by an hourglass-clock model.
|
| pubmed:affiliation |
Department of Physiology, University of Leiden, The Netherlands.
|
| pubmed:publicationType |
Journal Article
|