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rdf:type |
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lifeskim:mentions |
umls-concept:C0015576,
umls-concept:C0017337,
umls-concept:C0021027,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0043292,
umls-concept:C0086418,
umls-concept:C0679058,
umls-concept:C1413564,
umls-concept:C1547699,
umls-concept:C2700640
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pubmed:issue |
4
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|
pubmed:dateCreated |
1990-9-27
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pubmed:databankReference |
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pubmed:abstractText |
The murine and human genes for the L1 neural adhesion molecule were shown to lie on conserved regions of the X chromosome to which genes responsible for several neuromuscular diseases have been mapped and which are adjacent to the fragile site (FRAXA) associated with mental retardation. By pulsed-field gel mapping we have demonstrated physical linkage between the L1 gene and other genes located in Xq28: L1 lies between the eye pigment RCP, GCP locus and the glucose-6-phosphate dehydrogenase (G6PD) gene. This location is compatible with the implication of the L1 molecule in one of the X-linked neuromuscular diseases mapped to this region.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0888-7543
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
587-93
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:2387585-Amino Acid Sequence,
pubmed-meshheading:2387585-Animals,
pubmed-meshheading:2387585-Base Sequence,
pubmed-meshheading:2387585-Cell Adhesion Molecules, Neuronal,
pubmed-meshheading:2387585-Chromosome Banding,
pubmed-meshheading:2387585-Chromosome Mapping,
pubmed-meshheading:2387585-Fragile X Syndrome,
pubmed-meshheading:2387585-Genes,
pubmed-meshheading:2387585-Genetic Linkage,
pubmed-meshheading:2387585-Guanosine Diphosphate,
pubmed-meshheading:2387585-Humans,
pubmed-meshheading:2387585-Immunoglobulins,
pubmed-meshheading:2387585-Mice,
pubmed-meshheading:2387585-Molecular Sequence Data,
pubmed-meshheading:2387585-Multigene Family,
pubmed-meshheading:2387585-Nucleic Acid Hybridization,
pubmed-meshheading:2387585-Restriction Mapping,
pubmed-meshheading:2387585-Retinal Pigments,
pubmed-meshheading:2387585-Sequence Homology, Nucleic Acid,
pubmed-meshheading:2387585-X Chromosome
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pubmed:year |
1990
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pubmed:articleTitle |
The gene encoding L1, a neural adhesion molecule of the immunoglobulin family, is located on the X chromosome in mouse and man.
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pubmed:affiliation |
CIML INSERM-CNRS, Marseille, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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