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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
1990-9-18
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pubmed:abstractText |
Technetium-99m-DMG-2MP (Chloro[bis[2,3-butanedionedioxime(1-)-0][2,3- butanedionedioximato (2-)-N,N',N'',N''',N'''',N'''''] (2-methylpropyl borato (2-))technetium]), also known as SQ 32097 is a member of a family of neutral lipophilic compounds generally known as boronic acid adducts of technetium dioxime complexes (BATOs). After i.v. administration, the concentration of [99mTc]DMG-2MP in various regions of the brain appears to be proportional to blood flow. In rats, 1.1% ID was in the brain at 5 min postinjection when the blood contained less than 3% ID. Over 24 hr excretion was 59% in the feces and 23% in the urine. The activity in monkey brain at 5 min was 2.8% ID and it cleared with a t1/2 of 86 min. Autoradiographs of monkey brain sections showed excellent regional detail with a gray/white ratio of 3.6 at 10 min. The distribution of [99mTc]DMG-2MP in the monkey brain corresponds to the known cytoarchitectural pattern of cerebral glucose metabolism. The properties of [99mTc]DMG-2MP make it a potentially useful agent for cerebral perfusion imaging in man.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0161-5505
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1370-7
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:2384806-Animals,
pubmed-meshheading:2384806-Brain,
pubmed-meshheading:2384806-Cerebrovascular Circulation,
pubmed-meshheading:2384806-Female,
pubmed-meshheading:2384806-Macaca fascicularis,
pubmed-meshheading:2384806-Male,
pubmed-meshheading:2384806-Organotechnetium Compounds,
pubmed-meshheading:2384806-Oximes,
pubmed-meshheading:2384806-Radiation Dosage,
pubmed-meshheading:2384806-Rats,
pubmed-meshheading:2384806-Rats, Inbred Strains,
pubmed-meshheading:2384806-Species Specificity
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pubmed:year |
1990
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pubmed:articleTitle |
A neutral lipophilic technetium-99m complex for regional cerebral blood flow imaging.
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pubmed:affiliation |
Squibb Institute for Medical Research, New Brunswick, New Jersey 08903-0191.
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pubmed:publicationType |
Journal Article
|