| pubmed-article:2384544 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2384544 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2384544 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:2384544 | lifeskim:mentions | umls-concept:C1326356 | lld:lifeskim |
| pubmed-article:2384544 | lifeskim:mentions | umls-concept:C0683148 | lld:lifeskim |
| pubmed-article:2384544 | lifeskim:mentions | umls-concept:C0201874 | lld:lifeskim |
| pubmed-article:2384544 | lifeskim:mentions | umls-concept:C1524063 | lld:lifeskim |
| pubmed-article:2384544 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2384544 | pubmed:dateCreated | 1990-9-14 | lld:pubmed |
| pubmed-article:2384544 | pubmed:abstractText | A quantitative positron emission tomographic (PET) method to measure amino acid blood-brain barrier (BBB) transport rate and tissue distribution volume (DV) has been developed using 11C-labeled aminocyclohexanecarboxylate (ACHC), a nonmetabolized amino acid analogue. Dynamic PET data were acquired as a series of 15 scans covering a total of 60 min and analyzed by means of a two-compartment, two-parameter model. Functional images were calculated for the amino acid transport rate constants across the BBB and the amino acid DV in the brain. Results show [11C]ACHC to have an influx rate constant in gray matter of approximately 0.03-0.04 ml g-1 min-1, indicating a single-pass extraction fraction of approximately 5-7%. The intersubject coefficient of variation was approximately 15% while intrasubject variability of repeat scans was only slightly greater than 5%. Studies were performed in 15 young normal volunteer control subjects, 5 elderly controls, 7 patients with probable Alzheimer's disease, and one patient with phenylketonuria. Results indicate that [11C]-ACHC will serve as the basis of a method for measuring amino acid transport rate and DV in the normal and pathological human brain. | lld:pubmed |
| pubmed-article:2384544 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2384544 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2384544 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2384544 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2384544 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2384544 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2384544 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2384544 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2384544 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2384544 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2384544 | pubmed:issn | 0271-678X | lld:pubmed |
| pubmed-article:2384544 | pubmed:author | pubmed-author:AllenRR | lld:pubmed |
| pubmed-article:2384544 | pubmed:author | pubmed-author:AgranoffB WBW | lld:pubmed |
| pubmed-article:2384544 | pubmed:author | pubmed-author:LURIF AFA | lld:pubmed |
| pubmed-article:2384544 | pubmed:author | pubmed-author:CHUNC WCW | lld:pubmed |
| pubmed-article:2384544 | pubmed:author | pubmed-author:ShulkinB LBL | lld:pubmed |
| pubmed-article:2384544 | pubmed:author | pubmed-author:KoeppeR ARA | lld:pubmed |
| pubmed-article:2384544 | pubmed:author | pubmed-author:MangnerTT | lld:pubmed |
| pubmed-article:2384544 | pubmed:author | pubmed-author:KollrosPP | lld:pubmed |
| pubmed-article:2384544 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2384544 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:2384544 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2384544 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2384544 | pubmed:pagination | 727-39 | lld:pubmed |
| pubmed-article:2384544 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2384544 | pubmed:meshHeading | pubmed-meshheading:2384544-... | lld:pubmed |
| pubmed-article:2384544 | pubmed:meshHeading | pubmed-meshheading:2384544-... | lld:pubmed |
| pubmed-article:2384544 | pubmed:meshHeading | pubmed-meshheading:2384544-... | lld:pubmed |
| pubmed-article:2384544 | pubmed:meshHeading | pubmed-meshheading:2384544-... | lld:pubmed |
| pubmed-article:2384544 | pubmed:meshHeading | pubmed-meshheading:2384544-... | lld:pubmed |
| pubmed-article:2384544 | pubmed:meshHeading | pubmed-meshheading:2384544-... | lld:pubmed |
| pubmed-article:2384544 | pubmed:meshHeading | pubmed-meshheading:2384544-... | lld:pubmed |
| pubmed-article:2384544 | pubmed:meshHeading | pubmed-meshheading:2384544-... | lld:pubmed |
| pubmed-article:2384544 | pubmed:meshHeading | pubmed-meshheading:2384544-... | lld:pubmed |
| pubmed-article:2384544 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2384544 | pubmed:articleTitle | Use of [11C]aminocyclohexanecarboxylate for the measurement of amino acid uptake and distribution volume in human brain. | lld:pubmed |
| pubmed-article:2384544 | pubmed:affiliation | Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109-0552. | lld:pubmed |
| pubmed-article:2384544 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2384544 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2384544 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
