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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1975-10-11
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pubmed:abstractText |
The placental transport of alcohol and its effect on maternal and fetal acid-base balance studied in 10 sheep experiments by the maternal infusion of a 9.75 per cent solution of alcohol-dextrose at a rate of 15 c.c. per kilogram for 1 or 2 hours. Serial maternal and fetal blood sampling during and following the alcohol infusion revealed rapid placental diffusion of alcohol, a highly significant correlation between maternal and fetal blood alcohol concentrations, and a similar peak concentration of approximately 0.230 Gm. per 100 ml. in maternal and fetal blood that differed only in time of onset during the 1 and 2 hour infusion periods. Blood alcohol concentrations remained high for several hours during the postinfusion period. A significant maternal hyperlactacidemia and hyperglycemia were noted but did not result in significant alterations in maternal acid-base balance. An initial fetal metabolic acidosis and later mixed acidosis were observed during the alcohol infusion and worsened during the postinfusion period.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0002-9378
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
122
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
847-44
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:238397-Acid-Base Equilibrium,
pubmed-meshheading:238397-Animals,
pubmed-meshheading:238397-Aorta,
pubmed-meshheading:238397-Blood Glucose,
pubmed-meshheading:238397-Blood Pressure,
pubmed-meshheading:238397-Carbon Dioxide,
pubmed-meshheading:238397-Carotid Arteries,
pubmed-meshheading:238397-Ethanol,
pubmed-meshheading:238397-Female,
pubmed-meshheading:238397-Fetal Blood,
pubmed-meshheading:238397-Fetal Heart,
pubmed-meshheading:238397-Fetus,
pubmed-meshheading:238397-Heart Rate,
pubmed-meshheading:238397-Hydrogen-Ion Concentration,
pubmed-meshheading:238397-Infusions, Parenteral,
pubmed-meshheading:238397-Lactates,
pubmed-meshheading:238397-Maternal-Fetal Exchange,
pubmed-meshheading:238397-Oxygen,
pubmed-meshheading:238397-Placenta,
pubmed-meshheading:238397-Pregnancy,
pubmed-meshheading:238397-Sheep,
pubmed-meshheading:238397-Time Factors
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pubmed:year |
1975
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pubmed:articleTitle |
Placental transport of alcohol and its effect on maternal and fetal acid-base balance.
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pubmed:publicationType |
Journal Article
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