Linked Life Data

2383901

Source:http://linkedlifedata.com/resource/pubmed/id/2383901

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-9-20
pubmed:abstractText
The isotype distribution and idiotypic determinants of paraproteins (PP) found in sera from aging SJL mice were studied. One or more PP were found in 79% of 9-11 month old mice; the isotypes were gamma 1 greater than or equal to alpha greater than or equal to gamma 2a much greater than gamma 3 much greater than gamma 2b. There was a significant tendency for the PP to occur in pairs or triplets, multiple PP being found in 35% of the mice without an evident association between any two isotypes. Rabbit anti-Id was prepared against four isolated PP, two gamma 1 and two gamma 2a. Inhibition of anti-Id-Id interaction was specific for the immunizing PP only and was absent with all other PP studied (8 gamma 1 and 10 gamma 2 PP) and with normal SJL Ig. It is concluded that SJL PP fail to exhibit cross-reactive idiotypes and show a wider range of isotype distribution than was previously suspected, although PP of mu, delta, and epsilon isotypes are absent.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0008-8749
pubmed:author
pubmed:issnType
Print
pubmed:volume
129
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
494-502
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Paraproteins and primary lymphoma in SJL mice. I. Individuality of idiotypes on paraproteins.
pubmed:affiliation
Department of Pathology, New York University Medical Center, New York 10016.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.