Linked Life Data

238333

Source:http://linkedlifedata.com/resource/pubmed/id/238333

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1975-10-11
pubmed:abstractText
Extracellular acidosis (ph 5.9 to 6.5) was found to be significantly retard the subcellular response of Ehrlich ascites tumor cells (EATC) to anoxic injury. The cells initially showed a reversible stage of cell injury with diffuse mitrochondrial condensation and swelling of endoplasmic reticulum (ER) at pH 7.9 by 1 h, while by 3 h at this pH all cells showed high amplitude and intramatrical flocculent densities of mitochondria, and fragmentation of membrane systems. At pH 7.4 cells were normal at 15 min., the mitochondria were condensed as above by 1 h, some cells still showed condensed mitochondria and dilated ER while others showed high amplitude swelling of mitochondria by 3 h and all cells showed irreversible changes by 4 h. At pH 5.9 to pH 6.5 mitochondria remained condensed until 3 h and only by 6 h did some cells show high amplitude swelling, whereas most cells showed persistent mitrochondrial condensation. Not until 8 h did all cells show high amplitude swelling of mitochondria. Furthermore, ultrastructural differences in the pattern of necrosis were seen at the lower pH values consisting of greater density of the cell sap, irregularly dispersed flocculent densities in apposition to fragmented cytoplasmic membranes and in mitochondria, and more prominent persistent clumping of nuclear chromatin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0340-6075
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-16
pubmed:dateRevised
2009-10-27
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Studies on the modification of the cellular response to injury. II. Electron microscopic studies on the protective effect of acidosis on anoxic injury of Ehrlich ascites tumor cells.
pubmed:publicationType
Journal Article