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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-9-7
pubmed:abstractText
The effects of short- and long-term calcium replacement on myocardial function in six asymptomatic patients (age 48 +/- 3, mean +/- SEM) with hypocalcemia complicating surgical hypoparathyroidism were studied. Cardiac output was determined by ascending aortic continuous wave Doppler assessment and was measured as minute distance. During intravenous calcium replacement at rest, ascending aortic minute distance increased from 6.75 +/- 1.10 to 9.17 +/- 1.29 m as the calcium level rose from 1.76 +/- 0.08 to 2.06 +/- 0.19 mmol/L without changes in heart rate and blood pressure (p less than 0.01). The peak velocity and acceleration of blood flow derived from Doppler measurement showed a similar rise during calcium infusion. Symptom-limited cycle ergometry was performed before and 3 months after normalization of calcium by long-term oral therapy. Although the resting cardiac output was unchanged, the maximum cardiac output at peak exercise also increased from a minute distance of 11.58 +/- 1.84 to 15.37 +/- 2.28 m (p less than 0.05), together with an increase of maximum heart rate from 136 to 149 beats/min (p less than 0.05). Exercise duration was also prolonged from 11.9 +/- 2.9 to 13.0 +/- 2.8 minutes. Thus hypocalcemia impairs cardiac performance, but this impairment is reversible with calcium replacement.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0002-8703
pubmed:author
pubmed:issnType
Print
pubmed:volume
120
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
381-6
pubmed:dateRevised
2006-2-27
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Hypocalcemic myocardial dysfunction: short- and long-term improvement with calcium replacement.
pubmed:affiliation
Department of Medicine, University of Hong Kong, Queen Mary Hospital.
pubmed:publicationType
Journal Article