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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1990-9-12
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pubmed:abstractText |
Trichosporon beigelii caused fatal disseminated infections that were resistant to amphotericin B in two granulocytopenic patients. In vitro susceptibility studies demonstrated that both index strains of T. beigelii were inhibited but not killed by amphotericin B at achievable concentrations in serum. The minimum lethal concentration for both isolates was greater than or equal to 18 micrograms/ml. Five of seven other isolates were found to have a similar pattern of amphotericin B resistance. The fact that the minimum lethal concentration of T. beigelii was many times greater than its MIC was consistent with a resistance pattern of tolerance. We concluded that T. beigelii may be resistant in vitro to amphotericin B and that this in vitro resistance was correlated with refractory, disseminated trichosporonosis in granulocytopenic patients. T. beigelii should be included in the expanding list of amphotericin B-resistant fungi.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2380383-2644291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2380383-2647833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2380383-301053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2380383-3049842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2380383-3053920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2380383-3284339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2380383-3479819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2380383-3523114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2380383-3541129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2380383-3681380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2380383-3889042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2380383-3966747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2380383-6520227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2380383-6822746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2380383-6827136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2380383-727219
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0095-1137
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1616-22
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2380383-Adolescent,
pubmed-meshheading:2380383-Aged,
pubmed-meshheading:2380383-Agranulocytosis,
pubmed-meshheading:2380383-Amphotericin B,
pubmed-meshheading:2380383-Anemia, Aplastic,
pubmed-meshheading:2380383-Drug Resistance, Microbial,
pubmed-meshheading:2380383-Humans,
pubmed-meshheading:2380383-Male,
pubmed-meshheading:2380383-Microbial Sensitivity Tests,
pubmed-meshheading:2380383-Mitosporic Fungi,
pubmed-meshheading:2380383-Mycoses,
pubmed-meshheading:2380383-Opportunistic Infections,
pubmed-meshheading:2380383-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:2380383-Trichosporon
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pubmed:year |
1990
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pubmed:articleTitle |
Trichosporon beigelii, an emerging pathogen resistant to amphotericin B.
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pubmed:affiliation |
Infectious Diseases Section, National Cancer Institute, Bethesda, Maryland 20892.
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pubmed:publicationType |
Journal Article,
Case Reports
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