| pubmed-article:2380290 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2380290 | lifeskim:mentions | umls-concept:C0013227 | lld:lifeskim |
| pubmed-article:2380290 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:2380290 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2380290 | lifeskim:mentions | umls-concept:C0302908 | lld:lifeskim |
| pubmed-article:2380290 | lifeskim:mentions | umls-concept:C0680730 | lld:lifeskim |
| pubmed-article:2380290 | lifeskim:mentions | umls-concept:C0809874 | lld:lifeskim |
| pubmed-article:2380290 | lifeskim:mentions | umls-concept:C1148554 | lld:lifeskim |
| pubmed-article:2380290 | pubmed:dateCreated | 1990-9-12 | lld:pubmed |
| pubmed-article:2380290 | pubmed:abstractText | A sensitive and selective high-performance liquid chromatographic (HPLC) method was developed for the determination of the mucoregulatory drug CO/1408 in plasma and urine. Samples containing an internal standard were prepared for analysis using a simple clean-up procedure based on Extrelut solid-phase extraction and chromatographed using a reversed-phase analytical column. Isocratic elution with a mobile phase consisting of 25 mM phosphate buffer (pH 2.5)-acetonitrile-methanol [85:10:5 or 87:9:4 (v/v) for plasma or urine analysis, respectively] was effected at a flow-rate of 0.8 ml/min. The eluate was monitored with an ultraviolet-visible variable-wavelength detector at 200 nm. The limit of quantification for the assay of CO/1408 was 80 ng/ml for plasma and 1 per 0.1 ml for urine samples. In spite of the high solubility of CO/1408 in water, the recovery from plasma and urine was very good and reproducible. The method was found to be applicable to pharmacokinetic studies of the drug in the rat. | lld:pubmed |
| pubmed-article:2380290 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2380290 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2380290 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2380290 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2380290 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2380290 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2380290 | pubmed:month | May | lld:pubmed |
| pubmed-article:2380290 | pubmed:issn | 0021-9673 | lld:pubmed |
| pubmed-article:2380290 | pubmed:author | pubmed-author:VenturaPP | lld:pubmed |
| pubmed-article:2380290 | pubmed:author | pubmed-author:LoschiLL | lld:pubmed |
| pubmed-article:2380290 | pubmed:author | pubmed-author:GiromettaM... | lld:pubmed |
| pubmed-article:2380290 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2380290 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:2380290 | pubmed:volume | 507 | lld:pubmed |
| pubmed-article:2380290 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2380290 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2380290 | pubmed:pagination | 227-34 | lld:pubmed |
| pubmed-article:2380290 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2380290 | pubmed:meshHeading | pubmed-meshheading:2380290-... | lld:pubmed |
| pubmed-article:2380290 | pubmed:meshHeading | pubmed-meshheading:2380290-... | lld:pubmed |
| pubmed-article:2380290 | pubmed:meshHeading | pubmed-meshheading:2380290-... | lld:pubmed |
| pubmed-article:2380290 | pubmed:meshHeading | pubmed-meshheading:2380290-... | lld:pubmed |
| pubmed-article:2380290 | pubmed:meshHeading | pubmed-meshheading:2380290-... | lld:pubmed |
| pubmed-article:2380290 | pubmed:meshHeading | pubmed-meshheading:2380290-... | lld:pubmed |
| pubmed-article:2380290 | pubmed:meshHeading | pubmed-meshheading:2380290-... | lld:pubmed |
| pubmed-article:2380290 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2380290 | pubmed:articleTitle | High-performance liquid chromatographic determination of the mucoregulatory drug CO/1408 in rat plasma and urine. | lld:pubmed |
| pubmed-article:2380290 | pubmed:affiliation | Department of Biochemistry and Pharmacokinetics, Camillo Corvi SpA, Piacenza, Italy. | lld:pubmed |
| pubmed-article:2380290 | pubmed:publicationType | Journal Article | lld:pubmed |
