Linked Life Data

2379821

Source:http://linkedlifedata.com/resource/pubmed/id/2379821

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-9-12
pubmed:abstractText
The murine dilute suppressor gene, dsu, was previously shown to suppress the dilute coat color phenotypes of mice homozygous for the dilute (d), leaden (ln), and ashen (ash) mutations. Each of these mutations produce adendritic melanocytes, which results in an abnormal transportation of pigment granules into the hair shaft and a diluted coat color. The suppression of each mutation is associated with the restoration of near normal melanocyte morphology, indicating that dsu can compensate for the absence of normal d, ln and ash gene products. In experiments described here, we have determined whether dsu can suppress the coat color phenotype of 14 additional mutations, at 11 loci, that affect coat color by mechanisms other than alterations in melanocyte morphology. In no case was dsu able to suppress the coat color phenotype of these 14 mutations. This suggests that dsu acts specifically on coat color mutations that result from an abnormal melanocyte morphology. Unexpectedly, dsu suppressed the ruby eye color of ruby-eye (ru) and ruby-eye-2 (ru-2) mice, to black. The exact nature of the defect producing these two mutant phenotypes is unknown. Histological examination of the pigmented tissues of the eyes of these mice indicated that dsu suppresses the eye color by increasing the overall level of pigmentation in the choroid but not the retinal pigmented epithelium. Choroid melanocytes, like those in the skin, are derived from the neural crest while melanocytes in the retinal pigmented epithelium are derived from the optic cup. This suggests that dsu may act specifically on neural crest-derived melanocytes. These studies have thus identified a second group of genes whose phenotypes are suppressed by dsu and have provided new insights into the mechanism of action of dsu.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2379821, http://linkedlifedata.com/resource/pubmed/commentcorrection/2379821-16578176, http://linkedlifedata.com/resource/pubmed/commentcorrection/2379821-17247639, http://linkedlifedata.com/resource/pubmed/commentcorrection/2379821-17733087, http://linkedlifedata.com/resource/pubmed/commentcorrection/2379821-17807638, http://linkedlifedata.com/resource/pubmed/commentcorrection/2379821-2822532, http://linkedlifedata.com/resource/pubmed/commentcorrection/2379821-2895729, http://linkedlifedata.com/resource/pubmed/commentcorrection/2379821-3000867, http://linkedlifedata.com/resource/pubmed/commentcorrection/2379821-3141922, http://linkedlifedata.com/resource/pubmed/commentcorrection/2379821-4634048, http://linkedlifedata.com/resource/pubmed/commentcorrection/2379821-4761674, http://linkedlifedata.com/resource/pubmed/commentcorrection/2379821-4940552, http://linkedlifedata.com/resource/pubmed/commentcorrection/2379821-6031677, http://linkedlifedata.com/resource/pubmed/commentcorrection/2379821-6287001, http://linkedlifedata.com/resource/pubmed/commentcorrection/2379821-6305507, http://linkedlifedata.com/resource/pubmed/commentcorrection/2379821-6886377
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0016-6731
pubmed:author
pubmed:issnType
Print
pubmed:volume
125
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
421-30
pubmed:dateRevised
2010-9-10
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations.
pubmed:affiliation
Mammalian Genetics Laboratory, NCI-Frederick Cancer Research Facility, Maryland 21701.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.