Linked Life Data

2379799

Source:http://linkedlifedata.com/resource/pubmed/id/2379799

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-9-12
pubmed:abstractText
1. The present study was designed to verify the ACh-mediated role in the action of ClX using cardiovascular and non-cardiovascular tissues taken from rats. 2. In the vasa deferentia preparations the muscular twitch induced by TNS was not changed by atropine, however in the presence of this drug, ClX induced a significant reduction of the height of the TNS-evoked twitch. 3. In the cardiorespiratory experiments, the administration of ClX produced a dose-dependent decrease in MAP, HR and RF. These effects were not changed by bilateral vagotomy and cervical sympathectomy. 4. The results obtained with atropine and with bilateral vagotomy and sympathectomy, attempt to delineate the possibility of a direct action of ClX. 5. All the evidence taken together does not support the hypothesis that ClX may be acting through an indirect action by releasing ACh.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0306-3623
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
447-50
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Evidence that the action of clonixin is non-dependent of ACh release.
pubmed:affiliation
Department of Pharmacology, School of Medicine, Faculty of Medicine, Universidad de Chile, Santiago.
pubmed:publicationType
Journal Article, In Vitro