Linked Life Data

2379151

Source:http://linkedlifedata.com/resource/pubmed/id/2379151

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
1990-9-12
pubmed:abstractText
Twenty-four patients with metastatic colorectal carcinoma were treated with repeated doses (200-500 mg) of the mouse monoclonal antibody (MAb) 17-1A. Four different treatment schedules were used. The total dose was 1, 3.6, 7.6, and 12 g, respectively. Altogether, 263 infusions were administered. The interindividual variations in the maximum serum concentration at 2 h (max2 h) were large. The mean max2 h value after an infusion of 200 mg was 55 +/- 5 micrograms/ml and after 500 mg, 132 +/- 7 micrograms/ml. Max2 h concentration correlated inversely with the half-life of MAb 17-1A (P less than 0.001). The t1/2 beta for 200 mg was 25.9 +/- 1.4 h and after the administration of 500 mg, 19.8 +/- 1.0 h. The total area under the concentration versus time curve increased when high doses were administered on a continuous basis, in comparison with spaced infusions, thus increasing the exposure of the tumor tissues to MAb 17-1A. The pharmacokinetics of mouse MAb 17-1A are best described by a one-compartment model. All patients developed anti-mouse IgG antibodies and most also IgM antibodies. In the more intensive treatment schedules, the IgG antibody response was suppressed. Induction of high titers of anti-mouse antibodies did not cause clinical problems. Neither did they affect the pharmacokinetics of MAb 17-1A at these dose levels. Therapy was tolerated well. The side effects were mild and of short duration. The gastrointestinal adverse reactions were dose dependent and correlated to serum max2 h concentration. Allergic reactions were rare and easily clinically manageable.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4866-71
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Pharmacokinetics of the mouse monoclonal antibody 17-1A in cancer patients receiving various treatment schedules.
pubmed:affiliation
Department of Oncology (Radiumhemmet), Karolinska Hospital, Stockholm, Sweden.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't