Linked Life Data

2376779

Source:http://linkedlifedata.com/resource/pubmed/id/2376779

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1990-8-31
pubmed:abstractText
We have investigated the effects of prolonged systemic injections of nerve growth factor (NGF) and its antiserum on the survival and morphology of sympathetic ganglion cells in adult mice. Using intracellular injections of Lucifer yellow in lightly fixed superior cervical ganglia, we show that total dendritic lengths of ganglion cells are increased 29% after 2 weeks of NGF treatment. The increased dendritic length is characterized by increased branching within the dendritic arborization and not by the addition of new primary dendrites. In addition, cell soma cross-sectional area was increased 45%. Conversely, administration of NGF antiserum for 1 month decreased total dendritic length by 33%, decreased ganglion cell body size by 26%, and reduced the number of neurons in the ganglion by 25%. After 3 months of NGF antiserum treatment, the number of neurons in the ganglion was reduced a total of 41%. NGF antiserum treatment for 1 month in aged (22 months old) animals reduced ganglion cell body size by 21% and cell number by 22%, decreases that are comparable to those observed in young adult animals. Our results indicate that, even in maturity, sympathetic ganglion cells remain dependent on NGF for survival and maintenance of dendritic geometry, and this dependence continues into old age.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0270-6474
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2412-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Nerve growth factor regulates sympathetic ganglion cell morphology and survival in the adult mouse.
pubmed:affiliation
Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.