Linked Life Data

2376612

Source:http://linkedlifedata.com/resource/pubmed/id/2376612

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-9-4
pubmed:abstractText
SSM (specific substance of Maruyama) is used widely in cancer therapy. Rats and mice have generally been used in basic research. In this study the author used guinea pigs because their skin properties are easier to monitor than those of rats and mice. The following experiments were performed on guinea pigs: 1) Potency as sensitizer and elicitor of delayed hypersensitivity. 2) Antitumor effects on methylcholanthrene induced syngenic guinea pig tumors (U-1). Intradermal skin tests with 20 micrograms of SSM per 0.1 ml were done on guinea pigs 4 weeks after sensitization (SSM 1 mg-FIA (Freund's incomplete adjuvant]. SSM induced a delayed skin reactivity and the reaction increased in erythema and in duration after 24 h. In addition, SSM was active in direct inhibition of macrophage migration. The results show that SSM is related to cellular immunity reactions. In this study, antitumor effects of SSM were indicated in that the tumor growth was more greatly suppressed in animals injected intravenously and subcutaneously than in control animals. Histologic study of the tumors showed that collagen fibers enclosed the cancer cells and prevented cancer proliferation.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0048-0444
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
235-43
pubmed:dateRevised
2011-7-28
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
[Effects of SSM, an extract from human type tubercle bacilli, on syngenic guinea pig tumors].
pubmed:affiliation
Institute of Vaccine Therapy for Tumors and Infectious Diseases, Nippon Medical School, Japan.
pubmed:publicationType
Journal Article, English Abstract