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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1990-9-5
|
| pubmed:abstractText |
A computer-assisted morphometric study has been carried out on ethanol phosphotungstic acid (E-PTA) stained synaptic junctions in the human dentate gyrus supragranular layer from adult, old and Alzheimer's disease (AD)-affected patients. The number of synapses per unit volume of tissue (Nv = numerical density), the average area of the single junction (S) and the total area of the synaptic contact zones in a unit volume of tissue (Sv = surface density) were the 3 parameters taken into account. The synapse to neurone ratio was also calculated for each patient. During physiological aging, Nv and Sv significantly decreased and S increased, respectively. In the AD hippocampi, Nv and Sv underwent a further decrease which was in the range of more than 40% with reference to the adult values. S was the same as the old control group. In comparison with the adult values, the number of synapse/neurone decreased by 15.6 and 48% in old and AD patients, respectively. Nv, S and Sv, while reporting on discrete ultrastructural features of the synaptic junctional zones, are closely related to each other and, taken together per group of patients, may represent a reliable index of the morphological adaptive changes taking place at the synapses. Thus, the significant increase of S both in old and AD hippocampi may be regarded as a CNS plastic response to aging and disease, although the marked decrease of Nv and Sv supports that in AD synaptic ultrastructural alterations proceed beyond a critical threshold for functional recovery.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0006-8993
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
28
|
| pubmed:volume |
517
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
69-75
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2376007-Aged,
pubmed-meshheading:2376007-Aged, 80 and over,
pubmed-meshheading:2376007-Aging,
pubmed-meshheading:2376007-Alzheimer Disease,
pubmed-meshheading:2376007-Hippocampus,
pubmed-meshheading:2376007-Humans,
pubmed-meshheading:2376007-Image Processing, Computer-Assisted,
pubmed-meshheading:2376007-Middle Aged,
pubmed-meshheading:2376007-Synapses
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Morphological adaptive response of the synaptic junctional zones in the human dentate gyrus during aging and Alzheimer's disease.
|
| pubmed:affiliation |
Centre for Surgical Research, Gerontological Research Department INRCA, Ancona, Italy.
|
| pubmed:publicationType |
Journal Article
|