| pubmed-article:2375782 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2375782 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:2375782 | lifeskim:mentions | umls-concept:C1711254 | lld:lifeskim |
| pubmed-article:2375782 | lifeskim:mentions | umls-concept:C0595929 | lld:lifeskim |
| pubmed-article:2375782 | lifeskim:mentions | umls-concept:C0332197 | lld:lifeskim |
| pubmed-article:2375782 | lifeskim:mentions | umls-concept:C1704417 | lld:lifeskim |
| pubmed-article:2375782 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2375782 | pubmed:dateCreated | 1990-8-29 | lld:pubmed |
| pubmed-article:2375782 | pubmed:abstractText | Familial defective apolipoprotein B-100 is a genetic disorder which is associated with elevated plasma LDL levels. It appears to result from a G----A mutation at nucleotide 10,708 in exon 26 of the apolipoprotein B-100 gene leading to a substitution of glutamine for arginine at amino acid residue 3500. We explored the possible role of this point mutation as a cause of elevated plasma cholesterol among the Finns, a genetically isolated population in which both hypercholesterolemia and coronary heart disease are common: 552 hyperlipidemic patients from Western and Southern Finland were screened either by assaying patient sera with monoclonal antibody MB47 or by amplifying the region of the apo B gene containing the nucleotide 10,708 followed by hybridization of the amplified DNA with allele-specific oligonucleotide probes. Not a single individual with this particular mutation could be found. We conclude that familial defective apo B-100 is not a common cause of elevated plasma cholesterol in this population. | lld:pubmed |
| pubmed-article:2375782 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2375782 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2375782 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2375782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2375782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2375782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2375782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2375782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2375782 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2375782 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2375782 | pubmed:issn | 0021-9150 | lld:pubmed |
| pubmed-article:2375782 | pubmed:author | pubmed-author:TikkanenM JMJ | lld:pubmed |
| pubmed-article:2375782 | pubmed:author | pubmed-author:KontulaKK | lld:pubmed |
| pubmed-article:2375782 | pubmed:author | pubmed-author:HämäläinenTT | lld:pubmed |
| pubmed-article:2375782 | pubmed:author | pubmed-author:Aalto-SetäläK... | lld:pubmed |
| pubmed-article:2375782 | pubmed:author | pubmed-author:PalotieAA | lld:pubmed |
| pubmed-article:2375782 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2375782 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:2375782 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2375782 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2375782 | pubmed:pagination | 177-83 | lld:pubmed |
| pubmed-article:2375782 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2375782 | pubmed:meshHeading | pubmed-meshheading:2375782-... | lld:pubmed |
| pubmed-article:2375782 | pubmed:meshHeading | pubmed-meshheading:2375782-... | lld:pubmed |
| pubmed-article:2375782 | pubmed:meshHeading | pubmed-meshheading:2375782-... | lld:pubmed |
| pubmed-article:2375782 | pubmed:meshHeading | pubmed-meshheading:2375782-... | lld:pubmed |
| pubmed-article:2375782 | pubmed:meshHeading | pubmed-meshheading:2375782-... | lld:pubmed |
| pubmed-article:2375782 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2375782 | pubmed:articleTitle | Absence of familial defective apolipoprotein B-100 in Finnish patients with elevated serum cholesterol. | lld:pubmed |
| pubmed-article:2375782 | pubmed:affiliation | First Department of Medicine, University of Helsinki, Finland. | lld:pubmed |
| pubmed-article:2375782 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2375782 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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