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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1990-8-29
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pubmed:abstractText |
Familial defective apolipoprotein B-100 is a genetic disorder which is associated with elevated plasma LDL levels. It appears to result from a G----A mutation at nucleotide 10,708 in exon 26 of the apolipoprotein B-100 gene leading to a substitution of glutamine for arginine at amino acid residue 3500. We explored the possible role of this point mutation as a cause of elevated plasma cholesterol among the Finns, a genetically isolated population in which both hypercholesterolemia and coronary heart disease are common: 552 hyperlipidemic patients from Western and Southern Finland were screened either by assaying patient sera with monoclonal antibody MB47 or by amplifying the region of the apo B gene containing the nucleotide 10,708 followed by hybridization of the amplified DNA with allele-specific oligonucleotide probes. Not a single individual with this particular mutation could be found. We conclude that familial defective apo B-100 is not a common cause of elevated plasma cholesterol in this population.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein B-100,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins B,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0021-9150
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
177-83
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2375782-Apolipoprotein B-100,
pubmed-meshheading:2375782-Apolipoproteins B,
pubmed-meshheading:2375782-Base Sequence,
pubmed-meshheading:2375782-DNA,
pubmed-meshheading:2375782-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:2375782-Female,
pubmed-meshheading:2375782-Heterozygote,
pubmed-meshheading:2375782-Humans,
pubmed-meshheading:2375782-Hypercholesterolemia,
pubmed-meshheading:2375782-Hyperlipoproteinemia Type II,
pubmed-meshheading:2375782-Lipids,
pubmed-meshheading:2375782-Lipoproteins,
pubmed-meshheading:2375782-Male,
pubmed-meshheading:2375782-Molecular Sequence Data,
pubmed-meshheading:2375782-Mutation,
pubmed-meshheading:2375782-Polymerase Chain Reaction
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pubmed:year |
1990
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pubmed:articleTitle |
Absence of familial defective apolipoprotein B-100 in Finnish patients with elevated serum cholesterol.
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pubmed:affiliation |
First Department of Medicine, University of Helsinki, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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