Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1990-8-24
|
| pubmed:abstractText |
By using a combination of Southern blot hybridization analysis, polymerase-chain reaction amplification, and direct nucleotide sequencing, we studied deletions of mitochondrial DNA (mtDNA) in several nonfamilial patients with progressive external ophthalmoplegia and Kearns-Sayre syndrome, and in some of their direct relatives. Results suggest that the heteroplasmic mtDNA populations are already present at a very early stage of development, and that there is no direct transmission of mtDNA heteroplasmy by maternal inheritance.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0364-5134
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
94-7
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:2375642-Base Sequence,
pubmed-meshheading:2375642-Blotting, Southern,
pubmed-meshheading:2375642-DNA, Mitochondrial,
pubmed-meshheading:2375642-Humans,
pubmed-meshheading:2375642-Kearns-Sayre Syndrome,
pubmed-meshheading:2375642-Molecular Sequence Data,
pubmed-meshheading:2375642-Ophthalmoplegia,
pubmed-meshheading:2375642-Polymerase Chain Reaction,
pubmed-meshheading:2375642-Tissue Distribution
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Tissue distribution and transmission of mitochondrial DNA deletions in mitochondrial myopathies.
|
| pubmed:affiliation |
Department of Biochemistry and Genetics, Istituto Nazionale Neurologico, Carlo Besta, Milan, Italy.
|
| pubmed:publicationType |
Journal Article
|