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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
1990-8-29
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pubmed:abstractText |
A simplified and economical method for the attachment of 2'-deoxyribo, ribo and arabinonucleosides onto long-chain alkylamidopropanoic acid controlled-pore glass (LCAAP-CPG, P-3) is described. In this procedure, 5'-O-tritylated nucleosides are coupled directly to LCAAP-CPG in excellent yields using 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (DEC) as coupling reagent. The conventional and time-consuming preparation of nucleoside-3'-O-succinates is no longer required.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3813-21
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2374710-Acetic Anhydrides,
pubmed-meshheading:2374710-Arabinonucleosides,
pubmed-meshheading:2374710-Chemical Phenomena,
pubmed-meshheading:2374710-Chemistry,
pubmed-meshheading:2374710-Deoxyribonucleosides,
pubmed-meshheading:2374710-Dinucleoside Phosphates,
pubmed-meshheading:2374710-Glass,
pubmed-meshheading:2374710-Kinetics,
pubmed-meshheading:2374710-Methods,
pubmed-meshheading:2374710-Molecular Structure,
pubmed-meshheading:2374710-Oligonucleotides,
pubmed-meshheading:2374710-Pentachlorophenol,
pubmed-meshheading:2374710-Ribonucleosides
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pubmed:year |
1990
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pubmed:articleTitle |
An improved procedure for derivatization of controlled-pore glass beads for solid-phase oligonucleotide synthesis.
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pubmed:affiliation |
Department of Chemistry, Erindale College, University of Toronto, Mississauga, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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