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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1990-8-27
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pubmed:abstractText |
Phospholipase C (PLC) is shown to comprise at least nine isoforms. These isoforms can be separated into three structurally related classes. Within a class the isozymes have similar enzymological properties. In the case of the PLC gamma class, both isoforms may be regulated by tyrosine phosphorylation. For PLC gamma 1 we show that the tyrosine phosphorylation sites are contained within the SH2/SH3 region or 'modulatory domain'. The overexpression of PLC gamma 1 in Rat-2 cells results in increased phosphatidylinositol breakdown in response to PDGF treatment, demonstrating that PLC gamma 1 mediates this response. We note that thrombin activates PLC gamma 1 in addition to other PLC isoforms.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0300-5208
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
150
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
112-23; discussion 124-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2373024-Animals,
pubmed-meshheading:2373024-Calcium,
pubmed-meshheading:2373024-Cell Line,
pubmed-meshheading:2373024-DNA,
pubmed-meshheading:2373024-Gene Library,
pubmed-meshheading:2373024-Humans,
pubmed-meshheading:2373024-Inositol Phosphates,
pubmed-meshheading:2373024-Isoenzymes,
pubmed-meshheading:2373024-Kinetics,
pubmed-meshheading:2373024-Platelet-Derived Growth Factor,
pubmed-meshheading:2373024-Sequence Homology, Nucleic Acid,
pubmed-meshheading:2373024-Transfection,
pubmed-meshheading:2373024-Type C Phospholipases
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pubmed:year |
1990
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pubmed:articleTitle |
Phospholipase C isozymes: structural and functional similarities.
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pubmed:affiliation |
Genetics Institute, Cambridge, MA 02140.
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pubmed:publicationType |
Journal Article,
Comparative Study
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