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rdf:type |
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lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0021013,
umls-concept:C0021083,
umls-concept:C0035984,
umls-concept:C0086418,
umls-concept:C0229671,
umls-concept:C0441889,
umls-concept:C0591833,
umls-concept:C0681850,
umls-concept:C1280500,
umls-concept:C1511790,
umls-concept:C1524063,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C2349001,
umls-concept:C2697811,
umls-concept:C2754973
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pubmed:issue |
3
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pubmed:dateCreated |
1990-8-27
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pubmed:abstractText |
Anti-idiotypic antibodies (anti-Id Abs) are involved in the regulation of a number of immune responses including the IgE antibody production. In atopic patients, the increased synthesis of IgE antibodies could be related to a defective production of regulatory anti-Id Abs. In the present study, we first developed a sensitive assay for measuring the levels of anti-Id Abs directed against antibodies specific for Lol p I, the major allergenic determinant of Lolium perenne (rye grass). In this assay, we used previously described murine monoclonal anti-Lol p I antibodies that were shown to share epitopic specificities with human anti-Lol p I IgE and IgG antibodies, thus short-cutting the need for purification of F(ab')2 fragments of human IgG Abs and insuring optimal specificity and sensitivity. Levels of anti-Id Abs against two anti-Lol p I monoclonal antibodies (290A-167, 348A-6) were higher in normal volunteers than in untreated atopic patients. Specific immunotherapy increased the levels of anti-Id Abs to those of normal volunteers. These observations suggest a role for the Id-anti-Id network in the regulation of IgE antibody production.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372990-2421634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372990-2422284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372990-2439450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372990-2454883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372990-2460536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372990-2463482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372990-2951427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372990-3258278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372990-3261276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372990-3492316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372990-4142565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372990-6154241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372990-6207231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372990-6220058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372990-6402708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372990-6465622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372990-6607933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372990-6971876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372990-7086128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372990-985838
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
413-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2372990-Allergens,
pubmed-meshheading:2372990-Antibodies, Anti-Idiotypic,
pubmed-meshheading:2372990-Antibodies, Monoclonal,
pubmed-meshheading:2372990-Antibody Specificity,
pubmed-meshheading:2372990-Humans,
pubmed-meshheading:2372990-Immunoglobulin E,
pubmed-meshheading:2372990-Immunoglobulin G,
pubmed-meshheading:2372990-Plant Proteins,
pubmed-meshheading:2372990-Pollen,
pubmed-meshheading:2372990-Rhinitis, Allergic, Seasonal
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pubmed:year |
1990
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pubmed:articleTitle |
Detection of auto-anti-idiotypic antibodies to Lol p I (rye I) IgE antibodies in human sera by the use of murine idiotypes: levels in atopic and non-atopic subjects and effects of immunotherapy.
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pubmed:affiliation |
Unité de Recherche Inflammation et Immunologie-Rhumatologie Centre Hospitalier de l'Université Laval, Québec City, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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