| pubmed-article:2372486 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2372486 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:2372486 | lifeskim:mentions | umls-concept:C0333516 | lld:lifeskim |
| pubmed-article:2372486 | lifeskim:mentions | umls-concept:C0450442 | lld:lifeskim |
| pubmed-article:2372486 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:2372486 | lifeskim:mentions | umls-concept:C0078832 | lld:lifeskim |
| pubmed-article:2372486 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:2372486 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2372486 | pubmed:dateCreated | 1990-8-30 | lld:pubmed |
| pubmed-article:2372486 | pubmed:abstractText | The mechanism of tumour necrosis photosensitised by liposome-delivered Zn(II) phthalocyanine (Zn-Pc) has been studied in mice bearing a transplanted MS-2 fibrosarcoma. Ultrastructural analyses of tumour specimens obtained at different times after red light-irradiation (300 J cm-2, dose-rate 180 mW cm-2) indicate an early (3 h) photodamage of malignant cells especially at the level of the mitochondria and rough endoplasmic reticulum. The cellular damage becomes more evident between 6 h and 15 h after photodynamic therapy. On the other hand, the capillaries supplying the tumour tissue are modified at a much slower rate and appear to be severely damaged only after 15 h from irradiation, when the whole tissue becomes necrotic. Occasionally, mildly damaged capillaries are observed even at 72 h after irradiation. These findings support the hypothesis that low density lipoproteins (LDL) play a major role in the delivery of Zn-Pc to the tumour tissue; the photosensitiser is released specifically to malignant cells as a consequence of a receptor-mediated endocytosis of LDL. | lld:pubmed |
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| pubmed-article:2372486 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2372486 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2372486 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2372486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2372486 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2372486 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2372486 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:2372486 | pubmed:author | pubmed-author:JoriGG | lld:pubmed |
| pubmed-article:2372486 | pubmed:author | pubmed-author:MilanesiCC | lld:pubmed |
| pubmed-article:2372486 | pubmed:author | pubmed-author:ZhouCC | lld:pubmed |
| pubmed-article:2372486 | pubmed:author | pubmed-author:BioloRR | lld:pubmed |
| pubmed-article:2372486 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2372486 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:2372486 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2372486 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2372486 | pubmed:pagination | 846-50 | lld:pubmed |
| pubmed-article:2372486 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2372486 | pubmed:meshHeading | pubmed-meshheading:2372486-... | lld:pubmed |
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| pubmed-article:2372486 | pubmed:meshHeading | pubmed-meshheading:2372486-... | lld:pubmed |
| pubmed-article:2372486 | pubmed:meshHeading | pubmed-meshheading:2372486-... | lld:pubmed |
| pubmed-article:2372486 | pubmed:meshHeading | pubmed-meshheading:2372486-... | lld:pubmed |
| pubmed-article:2372486 | pubmed:meshHeading | pubmed-meshheading:2372486-... | lld:pubmed |
| pubmed-article:2372486 | pubmed:meshHeading | pubmed-meshheading:2372486-... | lld:pubmed |
| pubmed-article:2372486 | pubmed:meshHeading | pubmed-meshheading:2372486-... | lld:pubmed |
| pubmed-article:2372486 | pubmed:meshHeading | pubmed-meshheading:2372486-... | lld:pubmed |
| pubmed-article:2372486 | pubmed:meshHeading | pubmed-meshheading:2372486-... | lld:pubmed |
| pubmed-article:2372486 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2372486 | pubmed:articleTitle | Zn(II)-phthalocyanine as a photodynamic agent for tumours. II. Studies on the mechanism of photosensitised tumour necrosis. | lld:pubmed |
| pubmed-article:2372486 | pubmed:affiliation | Department of Biology, University of Padova, Italy. | lld:pubmed |
| pubmed-article:2372486 | pubmed:publicationType | Journal Article | lld:pubmed |
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