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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1990-8-30
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pubmed:abstractText |
The mechanism of tumour necrosis photosensitised by liposome-delivered Zn(II) phthalocyanine (Zn-Pc) has been studied in mice bearing a transplanted MS-2 fibrosarcoma. Ultrastructural analyses of tumour specimens obtained at different times after red light-irradiation (300 J cm-2, dose-rate 180 mW cm-2) indicate an early (3 h) photodamage of malignant cells especially at the level of the mitochondria and rough endoplasmic reticulum. The cellular damage becomes more evident between 6 h and 15 h after photodynamic therapy. On the other hand, the capillaries supplying the tumour tissue are modified at a much slower rate and appear to be severely damaged only after 15 h from irradiation, when the whole tissue becomes necrotic. Occasionally, mildly damaged capillaries are observed even at 72 h after irradiation. These findings support the hypothesis that low density lipoproteins (LDL) play a major role in the delivery of Zn-Pc to the tumour tissue; the photosensitiser is released specifically to malignant cells as a consequence of a receptor-mediated endocytosis of LDL.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372486-149996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372486-2956618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372486-2957705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372486-3231683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372486-3441494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372486-3628502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372486-3697992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372486-3712601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372486-3895684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372486-3967232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372486-6232631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372486-6234604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372486-6735758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372486-6994567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2372486-7198619
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
846-50
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2372486-Animals,
pubmed-meshheading:2372486-Fibrosarcoma,
pubmed-meshheading:2372486-Indoles,
pubmed-meshheading:2372486-Mice,
pubmed-meshheading:2372486-Mice, Inbred BALB C,
pubmed-meshheading:2372486-Microscopy, Electron,
pubmed-meshheading:2372486-Necrosis,
pubmed-meshheading:2372486-Organometallic Compounds,
pubmed-meshheading:2372486-Photochemotherapy,
pubmed-meshheading:2372486-Tumor Cells, Cultured
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pubmed:year |
1990
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pubmed:articleTitle |
Zn(II)-phthalocyanine as a photodynamic agent for tumours. II. Studies on the mechanism of photosensitised tumour necrosis.
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pubmed:affiliation |
Department of Biology, University of Padova, Italy.
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pubmed:publicationType |
Journal Article
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