Linked Life Data

2371922

Source:http://linkedlifedata.com/resource/pubmed/id/2371922

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1990-8-17
pubmed:abstractText
In the present study we investigated the possible role of neutrophils and the endothelium in the induction of hyperreactivity of pig coronary arteries to histamine. Histamine caused a dose-dependent contraction of isolated pig coronary arteries. The maximal contraction to histamine was reduced in preparations from which the endothelium had been removed. Pre-incubation of intact coronary arteries with isolated neutrophils had no influence on the contractile response to histamine. However, when the same experiments were performed with coronary arteries without endothelium, the maximal contraction to histamine was increased. Incubation with scavengers and inhibitors of the enzymes, lipoxygenase or cyclo-oxygenase, provided evidence for a role of lipoxygenase products in the induction of hyperreactivity to histamine by neutrophils in the pig coronary artery.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0065-4299
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
195-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Interaction between neutrophils and pig coronary artery increases histamine contractions.
pubmed:affiliation
Department of Pharmacology, Faculty of Pharmacy, University of Utrecht, The Netherlands.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't