Linked Life Data

2370245

Source:http://linkedlifedata.com/resource/pubmed/id/2370245

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-8-17
pubmed:abstractText
This study was aimed at assessing the pharmacokinetics of a single dose of theophylline solution (aminophylline 480 mg) administered by intramuscular (i.m.) route to 16 subjects (age 28-61 years, body weight 52-75 kg). The same dose was given a week apart by oral route in fasting conditions. The intraindividual comparison shows that by i.m. route the rate, but not the extent, of absorption may be somewhat lower. From the first hour on, until hour 3-4 after i.m. dosing, all subjects achieved a safe and effective serum theophylline concentration (9-17 mg/liter). This suggests that, although usually not recommended, self-administration of a single dose of aminophylline by i.m. route may temporarily help theophylline-responsive patients in distress, when other routes of administration are not available and facilities for intensive conventional treatment are lacking.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0277-0903
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
165-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Theophylline pharmacokinetics after intramuscular administration.
pubmed:affiliation
Ospedale Cervello, Palermo, Italy.
pubmed:publicationType
Journal Article, Comparative Study