Linked Life Data

2369652

Source:http://linkedlifedata.com/resource/pubmed/id/2369652

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-8-17
pubmed:abstractText
Hypervolemic infusion in rats of bis (3,5-dibromosalicyl) fumarate cross-linked hemoglobin (DBBF-Hb) to 40-60% of blood volume produced histologic lesions in retina which were not observed in rats similarly infused with human serum albumin or lactated Ringer's solution. Rats treated with 40% DBBF-Hb, exhibited intermittent zones of dense retinal pigmented epithelium while 60% DBBF-Hb animals exhibited severe inner retinal edema and retinal pigmented epithelium vacuolization, large focal zones of photoreceptor outer segment disruption and in one animal, subretinal hemorrhage. Light microscopic immunocytochemical evaluation of retinas with antibodies directed to human hemoglobin and albumin, showed the presence of both hemoglobin and albumin in this tissue. Transmission electron microscopy of the lesions demonstrated vacuolated retinal pigmented epithelial cells and large areas of focal photoreceptor outer segment disruption. We conclude that hypervolemic infusion disrupts the blood retinal barrier and that although both DBBF Hb and albumin cross, only hemoglobin produced damage in the retina.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0890-5533
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
299-307
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Morphologic alterations in rat retina after hypervolemic infusion of cross-linked hemoglobin.
pubmed:affiliation
Letterman Army Institute of Research, Presidio of San Francisco, CA 94129-6800.
pubmed:publicationType
Journal Article