Linked Life Data

2366703

Source:http://linkedlifedata.com/resource/pubmed/id/2366703

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-8-14
pubmed:abstractText
An oligolamellar lining which is probably phospholipid has been demonstrated on the gastric mucosal surface of the rat by transmission electron microscopy using fixation procedures specially developed to avoid the destruction of hydrophobic surfaces. This structure is unlikely to be an artefact since the use of two hydrophobic probes in epifluorescence microscopy gave emissions characteristic of oligolamellar phospholipid prepared in vitro. Moreover, lipid solvents almost eliminated both the fluorescence and the hydrophobicity. An oligolamellar lining was seen also on deeper structures, including oxyntic ducts and canaliculi in parietal cells, and it might offer a physical basis for the hitherto elusive gastric mucosal barrier. Parietal cells were also found to contain multilamellar bodies which, in the lung at least, represent phospholipid (surfactant) in a particularly surface-active form and one conducive to its deposition on tissue surfaces. This suggests that the parietal cell could gear the protection (surfactant) to the potential insult (acid) by secreting both together. The demonstration of a simple physical barrier preventing the stomach from digesting itself is discussed in regard to suggesting the use of certain surface-active foods which could be beneficial in preventing gastric ulcers and their recurrence after the acute phase has been treated using conventional therapies.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0025-729X
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
153
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
76-81
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
A physical identity for the gastric mucosal barrier.
pubmed:affiliation
Department of Physiology, University of New England, Armidale, NSW.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't