Linked Life Data

2366204

Source:http://linkedlifedata.com/resource/pubmed/id/2366204

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-8-13
pubmed:abstractText
Previous studies have demonstrated heterogeneity within lesional lymphocytes in drug-related oral lichen planus (D-LP) and idiopathic lichen planus (I-LP). This study examined the phenotype of Langerhans cells (LC) and keratinocytes in non-erosive D-LP and I-LP. In I-LP, keratinocytes expressed HLA-DR antigens whilst LC co-expressed CDIa, MHC Class II and CD4 antigens. The high levels of expression of MHC Class II antigens by LC were maintained during short term organ culture. In I-LP, the epithelium contained occasional CD25+ dendritic cells (putative activated LC). These cell phenotypes are suggestive of cell activation and likely result from local production of gamma interferon. In D-LP, expression of MHC Class II antigens on LC was reduced and no CD25+ cells were detected. The epithelium contained an increased number of CD45RA+ dendritic cells. While no differences between the production of interleukin-1 and interleukin-1 inhibitors by tissue samples could be detected, it is likely that the variations in epithelial cell phenotypes in I-LP and D-LP reflect altered cytokine production.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0904-2512
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
177-81
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Immunohistologic analysis of epithelial cell populations in oral lichen planus.
pubmed:affiliation
Department of Social and Preventive Dentistry, University of Queensland, Brisbane, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't