Linked Life Data

2365856

Source:http://linkedlifedata.com/resource/pubmed/id/2365856

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-8-15
pubmed:abstractText
The effects of concurrent administration of monensin sodium on the toxicity of progressively increasing oral doses of selenium (0.2 to 2.4 mg per kg body weight), given as sodium selenite twice weekly, have been examined in growing lambs. To link the chemically determined selenium concentration in tissues with observable pathological changes, the histochemical method of Danscher, which visualizes selenium bonds within tissues, was utilized. Findings included damage to conduction and contractile myofibres in the heart, segmental sarcoplasmal necrosis with lysis and atrophic change in skeletal musculature and selective accumulation of Danscher reaction-product in damaged areas of the liver, kidney and secondary lymphoid tissue. Concurrent administration of monensin sodium at a constant safe dosage enhanced the toxicity of selenium as demonstrated by increased severity of the signs of intoxication, fatalities, tissue selenium concentrations and intensified gross, histopathological and histochemical changes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-9975
pubmed:author
pubmed:issnType
Print
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
443-55
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Effects of concurrent oral administration of monensin on the toxicity of increasing doses of selenium in lambs.
pubmed:affiliation
Department of Veterinary Pathology, Royal Veterinary College, Hatfield, Herts, U.K.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't