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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1990-8-16
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pubmed:abstractText |
The phase structure of isolated bacterial lipid A, the lipid anchor of the lipopolysaccharides of the outer membrane of Gram-negative bacteria, has been investigated by neutron small-angle scattering. The shape of the scattering curves obtained at different H2O/2H2O ratios revealed a lamellar organisation of the lipid A at neutral pH both above and below its main phase temperature (approximately 40-45 degrees C). Analysis of the scattering curves and interpretation of the corresponding thickness distance distribution functions of the lamellar aggregates led to a model in which the lipid A molecules form a bilayer of about 5 nm in thickness. This value for the thickness of the bilayer, as well as the neutron-scattering density profile across the bilayer, can be explained by a molecular model which shows interdigitation of the fatty acid chains of the lipid A.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0014-2956
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
190
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
359-63
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pubmed:dateRevised |
2007-7-23
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pubmed:meshHeading |
pubmed-meshheading:2364950-Hydrogen-Ion Concentration,
pubmed-meshheading:2364950-Lipid A,
pubmed-meshheading:2364950-Lipid Bilayers,
pubmed-meshheading:2364950-Lipopolysaccharides,
pubmed-meshheading:2364950-Microscopy, Electron,
pubmed-meshheading:2364950-Models, Molecular,
pubmed-meshheading:2364950-Molecular Structure,
pubmed-meshheading:2364950-Neutrons,
pubmed-meshheading:2364950-Salmonella,
pubmed-meshheading:2364950-Scattering, Radiation,
pubmed-meshheading:2364950-Solutions,
pubmed-meshheading:2364950-Temperature
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pubmed:year |
1990
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pubmed:articleTitle |
Architecture of bacterial lipid A in solution. A neutron small-angle scattering study.
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pubmed:affiliation |
Robert Koch-Institut des Bundesgesundheitsamtes, Berlin.
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pubmed:publicationType |
Journal Article,
Comparative Study
|