Linked Life Data

2364803

Source:http://linkedlifedata.com/resource/pubmed/id/2364803

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-8-16
pubmed:abstractText
N-Nitrosodimethylamine (NDMA) is a potential carcinogen and present in our surroundings widely. NDMA can be formed by many precursors, Dimethylamine (DMA) is the most common precursor in food. To evaluate the risk of DMA nitrosation in vivo, so that men can do their best to reduce endogenous nitrosamine exposure, we carried out this research. This paper is the first part of our research. The stabilities of DMA and nitrite in the stomach were studied. DMA was stable and nitrite was decomposed at the speed of second-order reaction. The stabilities of nitrite in simulate gastric acid and in ascorbic (VC) solution also were studied. Nitrite decomposition in simulate gastric acid was very similar to the one in the stomach. VC solution at the equimolar with nitrite can decompose 53-79% of nitrite in one minute with shaking. We suggested that the efficiency of VC inhibiting endogenous nitrosation can be estimated on the basis of decomposing speed of nitrite and nitrosating speed by nitrite.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0253-9624
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
83-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
[Risk of endogenous N-nitrosodimethylamine formed by dimethylamine in rats--precursors stability].
pubmed:affiliation
Harbin Medical University.
pubmed:publicationType
Journal Article, English Abstract