| pubmed-article:2364432 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2364432 | lifeskim:mentions | umls-concept:C0021027 | lld:lifeskim |
| pubmed-article:2364432 | lifeskim:mentions | umls-concept:C0012925 | lld:lifeskim |
| pubmed-article:2364432 | lifeskim:mentions | umls-concept:C2248928 | lld:lifeskim |
| pubmed-article:2364432 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2364432 | pubmed:dateCreated | 1990-8-14 | lld:pubmed |
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| pubmed-article:2364432 | pubmed:abstractText | We have purified extrachromosomal circular DNAs from adult mouse spleen cells, and cloned into a phage vector the BamHl fragments hybridizing with C mu and S gamma 1 probes. We obtained 52 S mu+S gamma 1+ clones by screening 1.4 million phage clones derived from spleen cells stimulated with bacterial lipopolysaccharide and interleukin 4. We have identified the breakpoints of six clones that contain S gamma 1 and S mu sequences fused in the 5' to 3' orientation. All these switch recombination sites were assigned to the central repetitive sequences of the S mu and S gamma 1 regions. Since the common S mu-S gamma 1 sequences at the recombination sites are at most 2 bases long, typical homologous recombination cannot account for their joining. These findings provide direct evidence that mu-gamma 1 class switching can occur by the looping out and excision of chromosomal DNA, with formation of a circle. | lld:pubmed |
| pubmed-article:2364432 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2364432 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2364432 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2364432 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2364432 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2364432 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:2364432 | pubmed:author | pubmed-author:ShimizuAA | lld:pubmed |
| pubmed-article:2364432 | pubmed:author | pubmed-author:HonjoTT | lld:pubmed |
| pubmed-article:2364432 | pubmed:author | pubmed-author:YamagishiHH | lld:pubmed |
| pubmed-article:2364432 | pubmed:author | pubmed-author:IwasatoTT | lld:pubmed |
| pubmed-article:2364432 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2364432 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:2364432 | pubmed:volume | 62 | lld:pubmed |
| pubmed-article:2364432 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2364432 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2364432 | pubmed:pagination | 143-9 | lld:pubmed |
| pubmed-article:2364432 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2364432 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2364432 | pubmed:articleTitle | Circular DNA is excised by immunoglobulin class switch recombination. | lld:pubmed |
| pubmed-article:2364432 | pubmed:affiliation | Department of Biophysics, Faculty of Science, Kyoto University, Japan. | lld:pubmed |
| pubmed-article:2364432 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2364432 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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