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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1990-8-6
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pubmed:abstractText |
Polycystic liver disease (PLD) associated with autosomal dominant polycystic kidney disease is usually well tolerated. However there is a small subset of patients who become incapacitated by massive liver enlargement and for whom effective nonsurgical therapy is limited. Recent surgical advances in the treatment of PLD have raised uncertainties regarding proper management of these highly symptomatic patients. We have reviewed our recent experience with a combined hepatic resection-fenestration procedure to assess its efficacy in nine patients. All patients underwent resection of two or more liver segments and extensive fenestration of residual cysts in the remnant liver. Symptomatic relief and reduction in abdominal girth were obtained in eight surviving patients, persisting for an average follow-up period of 17 months. No progression of cystic disease has been observed clinically or by computed tomography and hepatic function was preserved. Three patients had no complications. Five patients had complications including transient right pleural effusion (3) and thrombosis of an arteriovenous fistula (2). One patient who had a previous hepatic cyst fenestration and a cadaveric renal transplantation died after operation of an intracerebral hemorrhage after experiencing coagulopathy, hyperbilirubinemia, and sepsis. Our results suggest (1) some highly symptomatic patients with massive PLD may benefit from combined hepatic resection and fenestration with acceptable risk, and (2) previous liver surgery and immunosuppressive therapy may increase the risk of such surgery. Longer follow-up is needed in a larger number of patients to determine the duration of benefit from the combined resection-fenestration procedure for highly symptomatic PLD.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-13422112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-13469269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-13534252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-14897088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-2983516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-3044063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-3178330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-3288024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-3655307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-3875218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-3880981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-3901732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-4296826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-4727970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-4816238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-4827034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-4835513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-5098229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-5107542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-5279738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-5684196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-596538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-6091444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-623374,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-6380124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-6424845,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-6697135,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-702498,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-707711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-7377224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-7403520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-7461397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-851133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-938229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2363601-973675
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0003-4932
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
212
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
30-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2363601-Adult,
pubmed-meshheading:2363601-Aged,
pubmed-meshheading:2363601-Cysts,
pubmed-meshheading:2363601-Drainage,
pubmed-meshheading:2363601-Female,
pubmed-meshheading:2363601-Humans,
pubmed-meshheading:2363601-Length of Stay,
pubmed-meshheading:2363601-Liver Diseases,
pubmed-meshheading:2363601-Liver Function Tests,
pubmed-meshheading:2363601-Male,
pubmed-meshheading:2363601-Methods,
pubmed-meshheading:2363601-Middle Aged,
pubmed-meshheading:2363601-Postoperative Complications,
pubmed-meshheading:2363601-Tomography, X-Ray Computed
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pubmed:year |
1990
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pubmed:articleTitle |
Treatment of highly symptomatic polycystic liver disease. Preliminary experience with a combined hepatic resection-fenestration procedure.
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pubmed:affiliation |
Department of Surgery, Mayo Clinic, Rochester, Minnesota.
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pubmed:publicationType |
Journal Article
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