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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7
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pubmed:dateCreated |
1990-8-6
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pubmed:abstractText |
In order to facilitate identification of possible metabolites arising from in vitro action of catechol-O-methyltransferase upon 7,8-dihydroxy- and 8,9-dihydroxy-4-n-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolines (11, 12), all four possible monomethyl ether derivatives have been synthesized. Incubation of 11 and 12 with the enzyme revealed that the 8,9-dihydroxy positional isomer 12 (which contains the dopamine moiety held in the beta conformation) but not the 7,8-dihydroxy isomer 11 (which holds the dopamine moiety in the alpha conformation) was a substrate for the enzyme. The sole detectable product of 12 was 8-hydroxy-9-methoxy derivative 15 in which the "meta" hydroxy group of the dopamine moiety is etherified.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-2623
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2000-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2362281-Animals,
pubmed-meshheading:2362281-Blood Pressure,
pubmed-meshheading:2362281-Catechol O-Methyltransferase,
pubmed-meshheading:2362281-Cats,
pubmed-meshheading:2362281-Female,
pubmed-meshheading:2362281-Heart Conduction System,
pubmed-meshheading:2362281-Heart Rate,
pubmed-meshheading:2362281-Hydroxyquinolines,
pubmed-meshheading:2362281-Indicators and Reagents,
pubmed-meshheading:2362281-Male,
pubmed-meshheading:2362281-Molecular Structure,
pubmed-meshheading:2362281-Spectrum Analysis,
pubmed-meshheading:2362281-Structure-Activity Relationship
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pubmed:year |
1990
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pubmed:articleTitle |
Monomethyl ether derivatives of 7,8-dihydroxy- and 8,9-dihydroxy-4-n-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolines as possible products of metabolism by catechol-O-methyltransferase.
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pubmed:affiliation |
Division of Medicinal and Natural Products Chemistry, College of Pharmacy, University of Iowa, Iowa City 52242.
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pubmed:publicationType |
Journal Article,
Comparative Study
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