Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-8-6
pubmed:abstractText
Cellular extraction and high-performance liquid chromatographic methods were developed for the isolation of etheno adducts from nucleotide pools formed in vivo following exposure to the chemical carcinogen ethyl carbamate. These techniques were employed to detect etheno adduct formation using BDF1 mice and rainbow trout (Salmo gairdneri) as test species following inter-peritoneal injection of the chemical. Ethenoadenine was detected in splenocyte nucleotide pools of mice after acute (24 h) exposure and chronic (two weeks) exposure. Several etheno adducts (i.e. ethenoadenine, etheno-AMP, etheno-ADP and etheno-ATP) were also detected in total spleen cell nucleotide pools of trout following acute ethyl carbamate exposure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0021-9673
pubmed:author
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
526
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
407-22
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Methods for the isolation and detection of etheno adducts in nucleotide pools in vivo following exposure to ethyl carbamate.
pubmed:affiliation
Program in Toxicology, Massachusetts Institute of Technology, Cambridge 02139.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't