Linked Life Data

2360774

Source:http://linkedlifedata.com/resource/pubmed/id/2360774

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-7-31
pubmed:abstractText
Four groups of 50 4-6-month old ewe-lambs were vaccinated with 1 or 2 living attenuated vaccines administered simultaneously. One hundred ewe-lambs received B melitensis strain REV 1 vaccine subcutaneously and 100 others received Rev 1 vaccine conjunctivally. In each group, 50 ewe-lambs simultaneously received the S abortusovis strain Rv6 vaccine via a contralateral subcutaneous route. Reactions to Brucella antigens (estimated by allergic intrapalpebral reaction to brucellin, complement fixation test and Rose Bengal plate test) or to S abortusovis antigens (agglutination of O and H antigens) were recorded. Agglutinating titers against Salmonella antigens increased in all animals vaccinated with Abortusovis Rv6, whatever the route of the associated Rev1 vaccination. Rv6 vaccination did not interfere with serological or allergic responses to Rev 1 vaccination 1 month after vaccination. Six months after vaccination, no interference was observed with serological reactions to Rev 1 vaccination, which were still positive in about 10% of subcutaneously vaccinated ewes and negative in all conjunctivally vaccinated ewes. However, 6 months after vaccination, the frequencies of allergic responses to Rev 1 vaccine were significantly decreased by Rv6 vaccination in the Rev 1 subcutaneously vaccinated (45 versus 24%, P less than 0.05), but not in the Rev 1 conjunctivally vaccinated groups (12 versus 17%). According to these serological and allergic criteria, 1), association of the 2 vaccines does not appear to interfere with detection of Brucellosis more than by using a single anti-Brucella vaccination; 2), immunogenicity of each vaccinal valence was demonstrated after simultaneous vaccination; and 3), anti-Brucella serological and allergic responses remained in any case lower after conjunctival vaccination than after subcutaneous Rev 1 injection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0003-4193
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
153-60
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Serological and allergic reactions of ewes after simultaneous vaccinations with two living attenuated strains of Brucella and Salmonella.
pubmed:affiliation
Institut National de la Recherche Agronomique, Unité de Pathologie Infectieuse Ovine, Nouzilly, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't